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Faculty of Science Radiation Sciences Graduate Program (RadGrad)
Faculty of Science

Radiation Sciences Graduate Program (RadGrad)

Michelle Lord

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PhD Student, Medical Physics

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  • My research is in the development of biomedical technology to detect gadolinium (Gd) in-vivo in humans. Gd is used worldwide in MRI contrast agents, which are administered prior to receiving an MRI in order to enhance certain features on the scan. Gd-based contrast agents were thought to be safe when introduced 30 years ago, and were expected to be excreted from the body within a few hours of administration. However, multiple studies have recently found Gd present in healthy individuals, suggesting that the Gd-based contrast agents are accumulating in the body. For this reason, the safety of Gd-based contrast agents is a topic of intense interest in the MRI community, making the potential for detection of Gd in vivo an exciting area of research. Gd is bone seeking, replacing Ca in bone mineral, which makes bone an excellent measurement site. Since all previous methods to measure Gd in bone have been invasive, I am developing the first non-invasive measurement devices through the technique of x-ray fluorescence and neutron activation analysis.

  • My other research interests include clinical medical physics, specifically radiation therapy.

  • Publications:

    Lord, M.L., McNeill, F.E., Gräfe, J.L., Noseworthy, M.D., Chettle, D.R. (2016). A phantom- based feasibility study for detection of gadolinium in bone in-vivo using x-ray fluorescence. Applied Radiation and Isotopes, 112, 103-109.

    Lord, M.L., McNeill, F.E., Gräfe, J.L., Galusha, A.L., Parsons, P.J., Noseworthy, M.D., Howard, L., Chettle, D.R. (2016). Confirming improved detection of gadolinium in bone using in vivo XRF. Submitted on August 3, 2016 to: Applied Radiation and Isotopes (ARI_2016_208).

    Conference Presentations:

    Lord, M.L.*, McNeill, F.E., Gräfe, J.L., Noseworthy, M.D., Chettle, D.R. (2016). Detection of gadolinium in bone using x-ray fluorescence. Oral presentation at the European Conference on X-ray Spectrometry, Gothenburg, Sweden (international). (PhD work)

    Lord, M.L.*, McNeill, F.E., Gräfe, J.L., Noseworthy, M.D., Chettle, D.R. (2016). A phantom- based feasibility study for detection of gadolinium in bone in-vivo using x-ray fluorescence. Poster Presentation at McMaster Bone Symposium (institutional). (Master’s work)

    Lord, M.L.*, McNeill, F.E., Gräfe, J.L., Noseworthy, M.D., Chettle, D.R. (2015). A phantom- based feasibility study for detection of gadolinium in bone in-vivo using x-ray fluorescence. Poster Presentation at International Society for Trace Element Research in Humans Conference, Dubrovnik, Croatia (international). Poster award winner. (Master’s work)

    Lord, M.L.*, Poepping, T.L. (2014). Multigate Spectral Doppler Displays of Simulated Flows. Poster presentation at London Imaging Discovery Day, Victoria Hospital, London, ON (regional). (NSERC USRA)

  • Physics 1D03 - Introductory Mechanics

    Physics 1A03 - Introductory Physics

    Med Phys 1E03 - Physics in Medicine and Biology

    Med Phys - 4B03 Radioactivity and Radiation Interactions

McMaster University - Faculty of Science

Mailing Address

McMaster University
General Sciences Building, Room 109
1280 Main Street West
Hamilton, Ontario, Canada
L8S 4K1

Contact Information

Office Hours:
9:00 a.m. - 4:00 p.m.
Telephone Inquiries:
+1 (905) 525-9140 ext.27650
Email Inquiries:
radgrad@mcmaster.ca

McMaster University - Faculty of Science

Mailing Address

McMaster University
General Sciences Building, Room 109
1280 Main Street West
Hamilton, Ontario, Canada
L8S 4K1

Contact Information

Office Hours:
9:00 a.m. - 4:00 p.m.
Telephone Inquiries:
(905) 525-9140 ext. 27650
Email Inquiries:
radgrad@mcmaster.ca