Office: Life Sciences Building 528
Phone: (905) 525-9140 ext. 20075
Fax: (905) 522-6066
My research is interdisciplinary and focused on the health effects to environmental stressors such as chemicals, temperature and radiation, on animals. These stressors are examined both individually and in combination; multiple stressors are much more difficult to study and yet represent more realistic of environmental exposures. Much of my research focuses on aquatic species such as fish. Reproduction and developmental are two physiological processes for which we are most interested.
Radiation work in my lab uses two different irradiation schemes. Acute, higher dose irradiation informs our research on the relative sensitivity of species to radiation, timing (e.g. developmental stage) of sensitivity, and potential interactions between radiation and other stressors. Chronic, low-dose irradiation informs on heath effects from more environmentally relevant exposures. Of specific interest to the nuclear community is my current work examining the effects of heat, chemicals, and radiation emitted into lake water from the use of once-through cooling processes by nuclear generating stations. This collaborative research project partners with industry to understand whether once through cooling impacts fish in the near shore area where the cooling water is released.
More recently, we have begun to study the effects of low dose radiation on fetal programming in mice. This research is more human health focused, as we try to understand whether low dose irradiation of pregnant mothers will result in health impacts for the offspring.
To find more out about my research, please visit my personal website.
Mitz, C., Thome, C., Thompson, J., Manzon, R. G., Wilson, J. Y., & Boreham, D. R. (2017). A method to transform a variable thermal regime to a physiologically equivalent effective temperature. Journal of Thermal Biology, 65, 21-25.
Verbueken, E., Alsop, D., Saad, M. A., Pype, C., Van Peer, E. M., Casteleyn, C. R., ... & Van Cruchten, S. J. (2017). In Vitro Biotransformation of Two Human CYP3A Probe Substrates and Their Inhibition during Early Zebrafish Development. International Journal of Molecular Sciences, 18(1), 217.
Eberts, R. L., Wissel, B., Simpson, G. L., Crawford, S. S., Stott, W., Hanner, R. H., ... & Somers, C. M. (2017). Isotopic Structure of Lake Whitefish in Lake Huron: Evidence for Regional and Local Populations Based on Resource Use. North American Journal of Fisheries Management, 37(1), 133-148.
Mueller, C. A., Doyle, L., Eme, J., Manzon, R. G., Somers, C. M., Boreham, D. R., & Wilson, J. Y. (2017). Lipid content and fatty acid profile during lake whitefish embryonic development at different incubation temperatures. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 203, 201-209.
Thome, C., Mitz, C., Somers, C. M., Manzon, R. G., Boreham, D. R., & Wilson, J. Y. (2016). Incubation of lake whitefish (Coregonus clupeaformis) embryos in cooling water discharge and the impacts of fluctuating thermal regimes on development. Canadian Journal of Fisheries and Aquatic Sciences, 73(8), 1213-1221.
Stefanovic, D.I., Manzon, L.A., Boreham, D.R., Somers, C.M., Wilson, J.Y., Manzon, R.G. 2016. Thermal Stress and the Heat Shock Response in Embryonic and Young of the Year Juvenile Lake Whitefish. Comparative Biochemistry and Physiology A, 193:1-10.
Graham, C., Glenn,T.C., McArthur, A., Boreham, D.R., Kieran, T., Lance, S. Manzon, R., Martino, J.A., Pierson, T.,Rogers, S.M., Wilson, J. and Somers, C.M. 2015. Impacts of degraded DNA on Restriction Enzyme Associated DNA Sequencing (RADSeq). Molecular Ecology Resources, 15:1304-1315.
Sreetharan, S., Thome, C., Mitz, C. Eme, J., Meuller, C, Hulley, E., Manzon, R.G., Somers, C.M., Boreham, D., and Wilson, J.Y. 2015. Embryonic development of lake whitefish (Coregonus clupeaformis): a staging series, analysis of growth and impacts of fixation. Journal of Fish Biology 87:539-558.
Mueller, C.A., Eme, J., Boreham, D., Manzon, R.G., Somers, C.M., and Wilson, J.Y. 2015. Embryonic Critical Windows: Changes in incubation temperature alter survival, hatchling phenotype, and cost of development in Lake whitefish (Coregonus clupeaformis) embryos. Journal of Comparative Physiology B, 185:315-331.
Eme, J., Mueller, C.A., Manzon, R., Somers, C.M., Boreham, D.R. and Wilson, J.Y. 2015.Critical windows in embryonic development: Shifting incubation temeraptures alter heart rate and oxygen consumption of Lake Whitefish (Coreogonus clupeaformis) embryos and hatchlings. Comparative Biochemstry and Phsyiology Part A Molecular and Integrative Physiology 179:71-80.
Dejong, C. and Wilson, J.Y* 2014. The cytochrome P450 superfamily complement (CYPome) in the annelid Capitella telata. PlosONE, 9:e107728.
Shaya, L, Dejong, C, and Wilson, J.Y. 2014.Expression patterns of cytochrome P450 3B and 3C genes in model fish species. Comparative Biochemistry and Physiology Part C Toxicology and Pharmacology 165:115-125.
Mitz, C, Thome, C, Cybulski, ME, LaFramboise, L, Wilson, JY1 and Boreham, D1. 2014. Small-scale rearing of Lake Whitefish (Coreogoneus clupeaformis) embryos for experimental aquaculture. North American Journal of Aquaculture 76:179-184.
Galus, M, Rangaranjan, S., Lai, A., Shaya, L., Balshine,S. and Wilson, J.Y. 2014. Effects of chronic, parental pharmaceutical exposure on zebrafish (Danio rerio) offspring. Aquatic Toxicology, 151:124-134.
Current Graduate Students
Charles Mitz, PhD
Shamaila Fraz, PhD
Lana Shaya, PhD
Michael Lim, MSc
Kristine Hammill, MSc
Adam Kulesza, MSc
Shayen Sreetharan, MSc
Biology 1A03 - Cellular and Molecular Biology
Biology 2A03 - Integrative Physiology of Animalsy
Pharmacology 3A06 - Introduction to Pharmacology
Biology 3ZZ3 - Topics in Physiology
Biology 3AA3 - Introduction to Pharmacology
Biology 4C09/4F06 - Senior Project/Thesis
Biology 726 - Topics in Integrative Physiology