Integrative Neuromuscular Biology Laboratory

Integrative Neuromuscular Biology Laboratoy

The focus of the research in the Integrative Neuromuscular Biology Laboratoy is to investigate molecular mechanisms of neuromuscular plasticity, with an emphasis on identifying new therapeutic strategies for neuromuscular disorders.
The central experimental questions that form the foundation of our research program are:

  1. What roles do phenotype-modifying proteins play in the maintenance and remodeling of the peripheral neuromuscular system, and
  2. Are these molecules efficacious therapeutic targets for inherited and acquired neuromuscular disorders?
To address these questions, we design investigations around lifestyle- and pharmacological-based strategies focused on the manipulation of powerful phenotype-bending molecules in the neuromuscular system. Furthermore, we employ an integrative and rigorous cell-to-animal experimental approach, as well as an innovative combination of molecular physiological solutions. A goal of our research is to decipher how interventions such as physical activity, experimental small molecules, and common generic medications can be used to slow, prevent, or reverse neuromuscular pathologies.
Department of Kinesiology | McMaster University has 1 registered member
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Associate Professor; Canada Research Chair (Tier 2) in Neuromuscular Plasticity in Health and Disease
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Research Interests:

Neuromuscular exercise biology; Duchenne muscular dystrophy; Spinal muscular atrophy; Myotonic dystrophy type 1; Sarcopenia of aging; AMP-activated protein kinase; Protein arginine methyltransferases

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McMaster University - Faculty of Science | Kinesiology